Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding.
Powell MS, Barnes NC, Bradford TM, Musgrave IF, Wines BD, Cambier JC, Hogarth PM
A common site of the Fc receptor gamma subunit interacts with the unrelated immunoreceptors FcalphaRI and FcepsilonRI.
Wines BD, Trist HM, Ramsland PA, Hogarth PM
Raft localisation of FcgammaRIIa and efficient signaling are dependent on palmitoylation of cysteine 208.
Barnes NC, Powell MS, Trist HM, Gavin AL, Wines BD, Hogarth PM
A competitive mechanism for staphylococcal toxin SSL7 inhibiting the leukocyte IgA receptor, Fc alphaRI, is revealed by SSL7 binding at the C alpha2/C alpha3 interface of IgA.
Wines BD, Willoughby N, Fraser JD, Hogarth PM
The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha RI binding and serum killing of bacteria.
Langley R, Wines B, Willoughby N, Basu I, Proft T, Fraser JD
Fc receptor gamma chain residues at the interface of the cytoplasmic and transmembrane domains affect association with FcalphaRI, surface expression, and function.
Wines BD, Trist HM, Monteiro RC, Van Kooten C, Hogarth PM