WHO ACTION-III trial: antenatal corticosteroids for improving outcomes in preterm newborns

We're trialing 2 doses of antenatal corticosteroids for women with a high probability of giving birth in the late preterm period. We're focusing on births in hospitals in low-resource countries with an aim to improve newborn outcomes. 

This is a multi-country, multi-centre, 3-arm, parallel group, double-blind, placebo controlled, randomized trial. The aim of this trial is to assess the benefits and possible harms of two regimens of antenatal corticosteroids, dexamethasone phosphate 4x6mg IM q12h and betamethasone phosphate 4x2mg IM q12h, compared to placebo, when given to pregnant women in the late preterm period (gestation age of 34+0 to 36+5 weeks) when they are at risk of preterm birth.

Timeline