Background

Joseph is a physician and researcher with a particular interest in the epidemiology, management and prevention of blood borne viruses (HIV, hepatitis C and hepatitis B).

With a background in clinical medicine, Joseph specialised in infectious diseases at the Alfred where he works as a consultant physician. He completed his MPH at the London School of Hygiene and Tropical Medicine and his public health fellowship was undertaken at the Victorian Infectious Diseases Reference Laboratory and Burnet Institute. His PhD at Burnet and Monash School of Population Health was focused on the effectiveness of early hepatitis C treatment.

Joseph is currently undertaking his NHMRC Postdoctoral Fellowship aiming to improve population health and treatment for hepatitis C infection at Burnet and Department of Infectious Diseases at Monash University. He is co-head of Viral Hepatitis Research and the clinical director of the hepatitis C TAP (Treatment and Prevention Study) at Burnet.

Appointments

• Deputy Program Director, Disease Elimination, Burnet Institute
• Co-Head, Viral Hepatitis Research, Burnet Institute
• NHMRC Clinical Research Fellow, Monash University
• Senior Research Fellow, Department of Infectious Diseases, Monash University
• Honorary Research Fellow, Department of Gastroenterology, St Vincent’s Hospital Melbourne
• Adjunct Senior Lecturer, School of Population Health and Preventive Medicine, Monash University
• Consultant Infectious Diseases Physician, The Alfred Hospital, Victoria, Australia

Positions

• 2015-2016: Postdoctoral Fellowship, Department of Gastroenterology, St Vincent’s Hospital and University of Melbourne
• 2011-2014: PhD Candidate, Burnet Institute, Centre for Population Health
• 2008-2011: Infectious Diseases Fellowship undertaken at the Royal Melbourne, Alfred and St Vincent’s Hospitals, and the Victorian Infectious Diseases Reference Laboratory, Victoria, Australia

Qualifications

• 2015: PhD, Monash University
• 2014: FAFPHM, Fellow of Australasian Faculty of Public Health Medicine, Australia
• 2011: FRACP in Infectious Diseases, Fellow of Royal Australasian College of Physicians, Australia
• 2006: MPH, London School of Hygiene and Tropical Medicine, United Kingdom
• 2005: BA (Hons), Department of Political Science, University of Melbourne, Victoria, Australia
• 2002: MBBS, University of Melbourne, Australia

Awards

• 2014: NHMRC Early Career Fellowship
• 2011: NHMRC Postgraduate Scholarship

Projects (13)

Current (9)

• Barriers to hepatocellular carcinoma screening uptake in Victoria
  In this study, we explore barriers to hepatocellular carcinoma screening adherence.
• co-EC Study: Eliminating hepatitis C/HIV coinfection
  Eliminating hepatitis C transmission by enhancing care and treatment among HIV co-infected individuals.
• DARE C: ATAHC II Substudy
  DARE-C aims to evaluate therapy duration using triple therapy (PEG-IFN/RBV/TPV).
• EC Australia: The vital missing link to eliminating hepatitis C
  Australia’s first nationally coordinated response to hepatitis C aims to achieve elimination by 2030.
• EC Partnership: Eliminate Hepatitis C Partnership
  Informing the elimination of HCV through a community-based nurse-led model of care and treatment.
• Natural history and response to treatment recent hepatitis C virus infection among a cluster of HCV genotype-1b infected individuals
  A cohort of women was exposed to hepatitis C virus (HCV) in a health care setting to a common source. The source was chronically infected with HCV genotype 1b.
• Rapid-EC hepatitis C Pilot Study
  Investigating the feasibility of providing rapid point-of-care testing for hepatitis C in community clinics.
• TAP: Treatment and Prevention Hep C study
  Does treating people who inject drugs for their hep C reduce transmission and prevalence?
• The Prime Study: Treating hep C in primary healthcare setting
  Examining feasibility of treating people with genotype 1 hepatitis C in primary healthcare setting.

Past (4)

• DAA based therapy for recently acquired hepatitis C – II (DARE-C II)
  To evaluate the combination of SOF plus RBV in patients with recently acquired HCV infection.
• Eliminating hepatitis C infection in Victoria through treatment scale up
  The project will aim to explore the supports needed for prescribers to start treatment for HCV infection.
• Examining hepatitis C reinfection among HIV co-infected gay and bisexual men
  This project will examine gay and bisexual men’s knowledge toward risk taking and hep C prevention.
• Hepatitis B infection in Australian prisons
  In this study, the seroprevalence of hepatitis B and D infection among prisoners will be determined.

Publications (49)

2019 (2)

• Improving hepatitis C direct-acting antiviral access and uptake: a role for patient-reported outcomes and lived-experience.
  Goutzamanis S, Doyle J, Higgs P, Hellard M
  J Viral Hepat. 2019 Jan; Epub ahead of print
• Aiming for the elimination of viral hepatitis in Australia, New Zealand, the Pacific Islands and Territories: where are we now and barriers to meeting WHO targets by 2030.
  Howell J, Pedrana A, Cowie BC, Doyle J, Getehun A, Ward J, Gane E, Cunningham C, Wallace J, Lee A, Malani J, Thompson A, Hellard ME
  J Gastroenterol Hepatol. 2019 Jan; Epub ahead of print

2018 (9)

• Eliminating hepatitis C: the importance of frequent testing of people who inject drugs in high prevalence settings.
  Scott N, Sacks-Davis R, Pedrana A, Doyle J, Thompson A, Hellard M
  J Viral Hepat. 2018 Jul; 25(12):1472-1480
• Community-based provision of direct-acting antiviral therapy for hepatitis C: study protocol and challenges of a randomized controlled trial.
  Wade AJ, Doyle JS, Gane E, Stedman C, Draper B, Iser D, Roberts SK, Kemp W, Petrie D, Scott N, Higgs P, Agius PA, Roney J, Stothers L, Thompson AJ, Hellard ME
  Trials. 2018 Jul; 19(1):383
• Eliminating HIV/HCV co-infection in gay and bisexual men: is it achievable through scaling up treatment?
  Sacks-Davis R, Pedrana AE, Scott N, Doyle JS, Hellard ME
  Expert Rev Anti Infect Ther. 2018 May; 16(5):411-422
• Experiences of liver health related uncertainty and self-reported stress among people who inject drugs living with hepatitis C virus: a qualitative study.
  Goutzamanis S, Doyle JS, Thompson A, Dietze P, Hellard M, Higgs P; TAP study group.
  BMC Infect Dis. 2018 Apr; 18(1):151
• Hepatitis C Patients Receiving Opioid Substitution Therapy Experience Improvement in Patient-Reported Outcomes Following Treatment with Interferon-Free Regimens.
  Stepanova M, Thompson A, Doyle J, Younossi I, de Avila L, Younossi ZM
  J Infect Dis. 2018 Apr; 217(17):1033-1043
• Linkage and retention in HCV care for HIV-infected populations: early data from the DAA era.
  Sacks-Davis R, Doyle JS, Rauch A, Beguelin C, Pedrana AE, Matthews GV, Prins M, van der Valk M, Klein MB, Saeed S, Lacombe K, Chkhartishvili N, Altice FL, Hellard ME
  J Int AIDS Soc. 2018 Apr; 21 Suppl 2:e25051
• Heterogeneity in hepatitis C treatment prescribing and uptake in Australia: a geospatial analysis of a year of unrestricted treatment access.
  Scott N, Hainsworth SW, Sacks-Davis R, Pedrana A, Doyle J, Wade A, Hellard M
  J Virus Erad. 2018 Apr; 4(2):108-114
• Effects of Pre-exposure Prophylaxis for the Prevention of HIV Infection on Sexual Risk Behavior in Men Who Have Sex with Men: A Systematic Review and Meta-analysis.
  Traeger MW, Schroeder SE, Wright EJ, Hellard ME, Cornelisse VJ, Doyle JS, Stoové MA
  Clin Infect Dis. 2018 Mar; 67(5):676-686
• Eliminating hepatitis C virus as a public health threat among HIV-positive men who have sex with men: a multi-modelling approach to understand differences in sexual risk behaviour.
  Scott N, Stoové M, Wilson DP, Keiser O, El-Hayek C, Doyle J, Hellard M
  J Int AIDS Soc. 2018 Jan; 21(1):e25059

2017 (6)

• Pathways to the elimination of hepatitis C: prioritising access for all.
  Pedrana AE, Sacks-Davis R, Doyle JS, Hellard ME
  Expert Rev Clin Pharmacol. 2017 Oct; 10(10):1023-1026
• Reaching hepatitis C virus elimination targets requires health system interventions to enhance the care cascade.
  Scott N, Doyle JS, Wilson DP, Wade A, Howell J, Pedrana A, Thompson A, Hellard ME
  Int J Drug Policy. 2017 Sep; 47:107-116
• New hepatitis C antiviral treatments eliminate the virus.
  Doyle JS, Thompson AJ, Higgs P, Stoove M, Dietze PM, Hellard ME
  Lancet. 2017 Jul; 390(10092):358-359
• Injecting drug use in low and middle income countries: opportunities to improve care and prevent harm.
  O'Keefe D, Stoové M, Doyle J, Dietze P, Hellard M.
  J Viral Hepat. 2017 Jun; 24(9):714-724
• A survey of hepatitis C management by Victorian GPs after PBS-listing of direct-acting antiviral therapy.
  Wade A, Draper B, Doyle J, Allard N, Grinzi P, Thompson A, Hellard M
  Aust Fam Physician. 2017 Apr; 46(4):235-240
• Treatment scale-up to achieve global HCV incidence and mortality elimination targets: a cost-effectiveness model.
  Scott N, McBryde ES, Thompson A, Doyle JS, Hellard ME
  Gut. 2017 Mar; 66(8):1507-1515

2016 (7)

• Direct-acting antiviral treatment for HCV.
  Goutzamanis S, Doyle J, Thompson A, Hellard M, Higgs P
  Lancet Infect Dis. 2016 Dec; 16(12):1325-6
• Field engagement further facilitates hepatitis B vaccination completion: Letter in response to: Day et al. (in press).
  Higgs P, Doyle J, Luppi J, Dietze P, Hellard M
  J Clin Virol. 2016 Jul; 82:64-65
• Quality of Life and Social Functioning during Treatment of Recent Hepatitis C Infection: A Multi-Centre Prospective Cohort.
  Doyle JS, Grebely J, Spelman T, Alavi M, Matthews GV, Thompson AJ, Dore GJ, Hellard ME; ATAHC Study Group.
  PLoS One. 2016 Jun; 11(6):e0150655
• Hepatitis C elimination by 2030 through treatment and prevention: think global, act in local networks.
  Hellard M, Sacks-Davis R, Doyle J
  J Epidemiol Commun Health. 2016 Jun; 70:1151-1154
• A systematic review of community based hepatitis C treatment.
  Wade AJ, Veronese V, Hellard ME, Doyle JS.
  BMC Infect Dis. 2016 May; 16(1):202
• Cost-effectiveness of treating chronic hepatitis C virus with direct-acting antivirals in people who inject drugs in Australia.
  Scott N, Iser D, Thompson A, Doyle J, Hellard M
  J Gastroenterol Hepatol. 2016 Feb; 31(4):872-882
• HIV and Sexual Risk Among Men Who Have Sex With Men and Women in Asia: A Systematic Review and Meta-Analysis.
  Bowring AL, Veronese V, Doyle JS, Stoové M, Hellard M
  AIDS Behav. 2016 Jan; 20(10):2243-2265

2015 (5)

• The Cascade of Care for an Australian Community-Based Hepatitis C Treatment Service.
  Wade AJ, Macdonald DM, Doyle JS, Gordon A, Roberts SK, Thompson AJ, Hellard ME
  PLoS One. 2015 Nov; 10(11):e0142770
• Response to treatment following recently acquired hepatitis C virus infection in a multicentre collaborative cohort.
  Doyle JS, Deterding K, Grebely J, Wedemeyer H, Sacks-Davis R, Spelman T, Matthews G, Rice TM, Morris MD, McGovern BH, Kim AY, Bruneau J, Lloyd AR, Page K, Manns MP, Hellard ME, Dore GJ and the InC3 Study Group.
  J Viral Hepat. 2015 Jun; 22(12):1020-1023
• Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis.
  Trauer JM, Qian MY, Doyle JS, W Rajaratnam SM, Cunnington D
  Ann Intern Med. 2015 Jun; 163(3):191-204
• Global policy and access to new hepatitis C therapies for people who inject drugs
  Doyle JS, Aspinall EJ, Hutchinson SJ, Quinn B, Gore C, Wiktor SZ, Hellard ME
  Int J Drug Policy. 2015 Jun; 26(11):1064-1071
• Targeted hepatitis C antibody testing interventions: a systematic review and meta-analysis.
  Aspinall EJ, Doyle JS, Corson S, Hellard ME, Hunt D, Goldberg D, Nguyen T, Falck-Ytter Y, Morgan RL, Smith B, Stoové M, Wiktor SZ, Hutchinson S
  Eur J Epidemiol. 2015 Feb; 30(2):115-129

2014 (6)

• Effects of HIV antiretroviral therapy on sexual and injecting risk-taking behaviour: a systematic review and meta-analysis.
  Doyle JS, Degenhardt L, Pedrana AE, McBryde ES, Guy R, Stoové MA, Weaver E, Grulich AE, Lo YR, Hellard M
  Clin Infect Dis. 2014 Aug; 59(10):1483-1494
• A systematic review of immediate HCV RNA testing following HCV Antibody compared with HCV RNA testing at time of assessment for HCV therapy.
  Hall K, Sacks-Davis R, Doyle J, Aspinall E, Hutchinson S, Hellard M
  Technical Report for the World Health Organisation, Global Hepatitis Programme, Geneva. 2014 Jul
• Latent tuberculosis screening using interferon-gamma release assays in an Australian HIV-infected cohort: is routine testing worthwhile?
  Doyle JS, Bissessor M, Denholm JT, Ryan N, Fairley CK, Leslie DE
  J Acquir Immune Defic Syndr. 2014 Jan; 66(1):48-54
• Eradication of hepatitis C infection: The importance of targeting people who inject drugs.
  Hellard M, Doyle JS, Sacks-Davis R, Thompson AJ, McBryde E
  Hepatology. 2014 Jan; 59(2):366-369
• Interferon-free hepatitis C treatment: one pill to fit all?
  Hellard ME, Doyle J
  Lancet. 2014 Jan; 383(9916):491-492
• Are needle and syringe programmes associated with a reduction in HIV transmission among people who inject drugs: a systematic review and meta-analysis.
  Aspinall EJ, Nambiar D, Goldberg DJ, Hickman M, Weir A, Van Velzen E, Palmateer N, Doyle JS, Hellard ME, Hutchinson SJ
  Int J Epidemiol. 2014 Jan; 43(1):235-248

2013 (9)

• Treatment of Hepatitis C Virus Infection Among People Who Are Actively Injecting Drugs: A Systematic Review and Meta-analysis.
  Aspinall EJ, Corson S, Doyle JS, Grebely J, Hutchinson SJ, Dore GJ, Goldberg DJ, Hellard ME
  Clin Infect Dis. 2013 Aug; 57 Suppl 2:S80-S89
• Direct acting antiviral therapy versus pegylated interferon and ribavirin treatment for chronic hepatitis C infection: a meta-analytical systematic review.
  Doyle JS, Thompson AJ, Aspinall EJ, Hutchinson SJ, Hellard ME
  Technical Report for the World Health Organisation, Global Hepatitis Programme. 2013 Jul
• A systematic review of the effectiveness of antiviral treatment compared with no treatment for chronic HCV.
  Doyle JS, Malandkar S, Aspinall EJ, Hall K, Hutchinson SJ, Hellard ME
  Technical Report for the World Health Organisation, Global Hepatitis Programme, Geneva. 2013 Jul
• A systematic review and meta-analysis of targeted HCV antibody testing interventions.
  Aspinall EJ, Doyle JS, Corson S, Hunt D, Hellard ME, Hutchinson SJ
  Technical Report for World Health Organisation, Global Hepatitis Programme, Geneva. 2013 Jul
• A systematic review of interventions to reduce alcohol consumption among individuals with chronic HCV infection.
  Hunt D, Doyle JS, Aspinall EJ, Hutchinson SJ, Hellard ME
  Technical Report for the World Health Organisation, Global Hepatitis Programme, Geneva. 2013 Jul
• Pegylated interferon plus ribavirin versus standard interferon plus ribavirin for chronic hepatitis C infection: a meta-analytical systematic review.
  Quinn B, Doyle JS, Howell J, Chow SM, Aspinall EJ, Hutchinson SJ, Hellard ME
  Technical Report for the World Health Organisation, Global Hepatitis Programme, Geneva. 2013 Jul
• Beyond injecting drug use: investigation of a Victorian cluster of hepatitis C among HIV-infected men who have sex with men.
  Mahony AA, Donnan EJ, Lester RA, Doyle JS, Knox J, Tracy SL, Bowden S, Sasadeusz JJ
  Med J Aust. 2013 Mar; 198(4):210-214
• Current and emerging antiviral treatments for hepatitis C infection.
  Doyle JS, Aspinall E, Liew D, Thompson AJ, Hellard ME
  Br J Clin Pharmacol. 2013 Mar; 75(4):931-43
• Assessing the cost-effectiveness of treating chronic hepatitis C virus in people who inject drugs in Australia.
  Visconti AJ, Doyle JS, Weir A, Shiell AM, Hellard ME
  J Gastroenterol Hepatol. 2013 Jan; 28(4):707-16

2012 (2)

• The role of viral and host genetics in natural history and treatment of chronic HCV infection.
  Doyle JS, Hellard ME, Thompson AJ
  Best Pract Res Clin Gastroenterol. 2012 Aug; 26(4):413-427
• Murray Valley encephalitis: a review of clinical features, diagnosis and treatment.
  Knox J, Cowan RU, Doyle JS, Ligtermoet MK, Archer JS, Burrow JN, Tong SY, Currie BJ, Mackenzie JS, Smith DW, Catton M, Moran RJ, Aboltins CA, Richards JS
  Med J Aust. 2012 Mar; 196(5):322-326

2011 (3)

• Epidemiology of infections acquired in intensive care units.
  Joseph S Doyle, Kirsty L Buising, Karin A Thursky, Leon J Worth, Michael J Richards
  Semin Respir Crit Care Med. 2011 Apr; 32(2):115-138
• Mumps presenting as epididymo-orchitis among young travellers: under-recognition, missed diagnoses and transmission risks.
  Joseph S Doyle, Emma K Paige, Denis W Spelman
  Med J Aust. 2011 Mar; 194(6):317-318
• Balamuthia mandrillaris brain abscess successfully treated with complete surgical excision and prolonged combination antimicrobial therapy.
  Doyle JS, Campbell E, Fuller A, Spelman DW, Cameron R, Malham G, Gin D, Lewin SR
  J Neurosurg. 2011 Feb; 114(2):458-462

News Articles (19)

2018 (3)

• EC Australia: The missing link to hepatitis C elimination
• Hepatitis elimination efforts in great hands
• Scholarships for Burnet alumni

2017 (4)

• Burnet World Hepatitis Day Symposium
• Hep C treatment decline prompts new call out
• The case for new hepatitis C treatments
• Dr Joseph Doyle is 2017 Gust-McKenzie Medallist

2016 (9)

• Hep C: Elimination is the Goal
• Burnet launches Eliminate Hep C strategy
• 2020 vision for Hep C elimination
• Hep C co-EC study showcased at AIDS 2016
• NHMRC grant to assist hepatitis C research
• Australia a potential world leader to eliminate hepatitis C
• Historic partnership aims to end hep C within a decade
• Landmark day with listing of hepatitis C drugs on PBS scheme
• TAP Study: A key to hepatitis C elimination

2014 (3)

• Travel Awards to enhance Burnet research
• AIDS 2014: Burnet Institute research showcased
• First-ever hepatitis C treatment guidelines released