Projects (10)

Current (8)

• A novel gel for targeting vaginal inflammation to prevent HIV transmission
  Developing an intravaginal gel delivering a vaginal microbiota metabolite.
• Antimicrobial and immune modulatory effects of vaginal microbiota metabolites
  Determining the role of vaginal microbiota metabolites in activating HIV and other STIs.
• Getting to the heart of cardiovascular disease in HIV
  Investigating the pathogenesis of cardiovascular disease in HIV infection and identifying clinically useful predictors and therapies.
• Impact of a vaginal microbiota metabolite on epithelium integrity and HIV susceptibility
  Determining the role of a vaginal microbiota metabolite in enhancing the mucosal barrier to prevent HIV transmission.
• Targeting HIV-infected macrophages to achieve an HIV cure
  Optimising methods to target and kill HIV-infected macrophages using Natural Killer cells.
• The impact of viral infections on immune ageing.
  Characterising the impact of chronic and acute viral infections on immune ageing, immune dysfunction, and development of age-related diseases.
• The persistence of HIV in monocytes and macrophages
  Investigating the size and characteristics of the HIV reservoir in monocytes and macrophages that persists despite anti-HIV therapy.
• The role of monocytes in the development of cardiovascular disease
  Examining how monocytes drive the thickening of the artery wall.

Past (2)

• Addressing the healthcare needs of people ageing with HIV in Victoria
  Identifying requirements and gaps in Victoria and influence policy for government.
• Human endogenous retroviruses (HERVs) and disease
  To determine whether gammaretroviruses are associated with prostate cancer.

Publications (44)

2020 (2)

• Distinct Immune Responses Elicited From Cervicovaginal Epithelial Cells by Lactic Acid and Short Chain Fatty Acids Associated With Optimal and Non-optimal Vaginal Microbiota.
  Delgado-Diaz DJ, Tyssen D, Hayward JA, Gugasyan R, Hearps AC, Tachedjian G
  Front Cell Infect Microbiol. 2020 Jan; 9:446
• Monocytes from men living with HIV exhibit heightened atherogenic potential despite long term viral suppression with ART.
  Angelovich TA, Trevillyan JM, Hoy JF, Wong ME, Agius PA, Hearps AC, Jaworowski A
  AIDS. 2020 Jan; Epub ahead of print

2019 (3)

• The HIV Reservoir in Monocytes and Macrophages.
  Wong ME, Jaworowski A, Hearps AC
  Front Immunol. 2019 Jun; 10:1435
• How Monocytes Contribute to Increased Risk of Atherosclerosis in Virologically-Suppressed HIV-Positive Individuals Receiving Combination Antiretroviral Therapy.
  Jaworowski A, Hearps AC, Angelovich TA, Hoy JF
  Front Immunol. 2019 Jun; 10:1378
• Molecular Dissection of an Inhibitor Targeting the HIV Integrase Dependent Pre-Integration Complex Nuclear Import.
  Wagstaff KM, Headey S, Telwatte S, Tyssen D, Hearps AC, Thomas DR, Tachedjian G, Jans DA
  Cell Microbiol. 2019 Jan; 21(1):e12953

2018 (2)

• Suppression of monocyte inflammatory and coagulopathy responses in HIV infection.
  Rajasuriar R, Hearps AC, Crowe SM, Anzinger JJ, Palmer CS
  Ann Transl Med. 2018 Jul; 6(13):277
• Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome.
  Opat S, Hearps A, Thia K, Yuen A, Rogers B, Chachage M, Moore G, Shortt J, Ryland G, Blombery P, Schwarer AP, Noori T, Trapani JA, Jaworowski A, Voskoboinik I
  Blood. 2018 Jan; 131(6): 699-702

2017 (8)

• Dysfunctional HDL from HIV+ individuals promotes monocyte-derived foam cell formation in vitro.
  Angelovich TA, Hearps AC, Oda MN, Borja MS, Huynh D, Homann S, Jaworowski A, Kelesidis T
  AIDS. 2017 Nov; 31(17):2331-2336
• Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions.
  Angelovich TA, Hearps AC, Maisa A, Kelesidis T, Jaworowski A
  J Vis Exp. 2017 Oct; 128:e56293
• Cell-free biochemical fluorometric enzymatic assay for high-throughput measurement of lipid peroxidation in high density lipoprotein.
  Sen Roy S, Nguyen HCX, Angelovich TA, Hearps AC, Huynh D, Jaworowski A, Kelesidis T
  J Exp Vis. 2017 Oct; 128:e56325
• Persistence of activated and adaptive-like NK cells in HIV+ individuals despite 2 Years of suppressive combination antiretroviral therapy.
  Hearps AC, Agius PA, Zhou J, Brunt S, Chachage M, Angelovich TA, Cameron PU, Giles M, Price P, Elliott J, Jaworowski A
  Front Immunol. 2017 Jun; 8:731
• Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition.
  Hearps AC, Tyssen D, Srbinovski D, Bayigga L, Diaz DJD, Aldunate M, Cone RA, Gugasyan R, Anderson DJ, Tachedjian G
  Mucosal Immunol. 2017 Apr; 10(6):1480-1490
• Porphyromonas gingivalis antibody levels and diagnosis of coronary artery disease in HIV-positive individuals.
  Berquist VL, Hearps AC, Ford P, Jaworowski A, Leishman SJ, Hoy JF, Trevillyan JM
  J Periodontal Res. 2017 Apr; 52(5):930-935
• High levels of transmitted HIV drug resistance in a study in Papua New Guinea.
  Lavu E, Kave E, Mosoro E, Markby J, Aleksic E, Gare J, Elsum IA, Nano G, Kaima P, Dala N, Gurung A, Bertagnolio S, Crowe SM, Myatt M, Hearps AC, Jordan MR
  PLoS One. 2017 Feb; 12(2):e0170265
• Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals.
  Trevillyan JM, Gardiner EE, Andrews RK, Maisa A, Hearps AC, Al-Tamimi M, Crowe SM, Hoy JF
  Platelets. 2017 Jan; 28(3):301-304

2016 (2)

• Increasing Prevalence of Synonymous Mutations K65K and K66K in HIV-1 subtype B reverse transcriptase.
  Telwatte S, Brumme CJ, Hearps AC, Latham CF, Hayward JA, Sonza S, Sluis-Cremer N, Harrigan PR, Tachedjian G
  AIDS. 2016 Sep; 30(18):2787-2793
• Ex vivo foam cell formation is enhanced in monocytes from older individuals by both extrinsic and intrinsic mechanisms.
  Angelovich TA, Shi MD, Zhou J, Maisa A, Hearps AC, Jaworowski A
  Exp Gerontol. 2016 Apr; 80:17-26

2015 (7)

• Factors Influencing Antiretroviral Adherence and Virological Outcomes in People Living with HIV in the Highlands of Papua New Guinea.
  Gare J, Kelly-Hanku A, Ryan CE, David M, Kaima P, Imara U, Lote N, Crowe SM, Hearps AC
  PLoS One. 2015 Aug; 10(8):e0134918
• Monocytes from HIV+ individuals show impaired cholesterol efflux and increased foam cell formation after transendothelial migration.
  Maisa A, Hearps AC, Angelovich TA, Pereira CF, Zhou J, Shi MDY, Palmer CS, Muller WA, Crowe SM, Jaworowski A
  AIDS. 2015 Jun; 29(12):1445-1457
• Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis.
  Aldunate M, Srbinovski D, Hearps AC, Latham CF, Ramsland PA, Gugasyan R, Cone RA, Tachedjian G
  Front Physiol. 2015 Jun; 6:164
• An NK Cell Population Lacking FcRgamma Is Expanded in Chronically Infected HIV Patients.
  Zhou J, Amran FS, Kramski M, Angelovich TA, Elliott J, Hearps AC, Price P, Jaworowski A
  J Immunol. 2015 Apr; 194(10):4688-4697
• Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations.
  Telwatte S, Hearps AC, Johnson A, Latham CF, Moore K, Agius P, Tachedjian M, Sonza S, Sluis-Cremer N, Harrigan PR, Tachedjian G
  Nucleic Acids Res. 2015 Mar; Epub ahead of print
• Inflammation-induced foam cell formation in chronic inflammatory disease.
  Angelovich TA, Hearps AC, Jaworowski A
  Immunol Cell Biol. 2015 Mar; 93(8):683-693
• Viremic and virologically suppressed HIV infection increases age-related changes to monocyte activation equivalent to 12 and 4 years of ageing respectively.
  Angelovich TA, Hearps AC, Maisa A, Martin GE, Lichtfuss GF, Cheng WJ, Palmer CS, Landay AL, Crowe SM, Jaworowski A
  J Acquir Immune Defic Syndr. 2015 Feb; 69(1):11-17

2014 (6)

• The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure.
  Campbell JH, Hearps AC, Martin GE, Williams KC, Crowe SM
  AIDS. 2014 Aug; 28 (15):2175-2187
• Inflammation and innate immune activation in chronic HIV infection.
  Jaworowski A, Hearps AC
  Microbiol Aust. 2014 May; 35(2):101-102
• Presence of HIV drug resistance in antiretroviral therapy-naive and -experienced patients from Papua New Guinea.
  Gare J, Ryan CE, David M, Timbi D, Kaima P, Kombati Z, Imara U, Kelly-Hanku A, Siba PM, Crowe SM, Hearps AC
  J Antimicrob Chemother. 2014 Apr; 69(8):2183-2186
• Inflammatory co-morbidities in HIV+ individuals: Learning lessons from healthy ageing.
  Hearps AC, Martin GE, Rajasuriar R, Crowe SM
  Curr HIV/AIDS Rep. 2014 Jan; 11(1):20-23
• Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals.
  Westhorpe CL, Maisa A, Spelman T, Hoy JF, Dewar EM, Karapanagiotidis S, Hearps AC, Cheng WJ, Trevillyan J, Lewin SR, Sviridov D, Elliott JH, Jaworowski A, Dart AM, Crowe SM
  Immunol Cell Biol. 2014 Jan; 92(2):133-138
• Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection.
  Palmer CS, Ostrowski M, Gouillou M, Tsai L, Yu D, Zhou J, Henstridge DC, Maisa A, Hearps AC, Lewin SR, Landay A, Jaworowski A, McCune JM, Crowe SM
  AIDS. 2014 Jan; 28(3):297-309

2013 (5)

• Acquisition of HIV by African-Born Residents of Victoria, Australia: Insights from Molecular Epidemiology.
  Lemoh C, Ryan CE, Sekawi Z, Hearps AC, Aleksic E, Chibo D, Grierson J, Baho S, Street A, Hellard M, Biggs BA, Crowe SM
  PLoS One. 2013 Dec; 8(12):e84008
• First molecular epidemiology study of Mycobacterium tuberculosis in Kiribati.
  Aleksic E, Merker M, Cox H, Reiher B, Sekawi Z, Hearps AC, Ryan CE, Lee AV, Goursaud R, Malau C, O'Connor J, Cherry CL, Niemann S, Crowe SM
  PLoS One. 2013 Jan; 8(1):e55423
• Age-Associated Changes in Monocyte and Innate Immune Activation Markers Occur More Rapidly in HIV Infected Women.
  Martin GE, Gouillou M, Hearps AC, Angelovich TA, Cheng AC, Lynch F, Cheng WJ, Paukovics G, Palmer CS, Novak RM, Jaworowski A, Landay AL, Crowe SM
  PLoS One. 2013 Jan; 8(1):e55279
• No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.
  Rezaei SD, Hearps AC, Mills J, Pedersen J, Tachedjian G
  Virol J. 2013 Jan; 10(1):20
• Inhibition of telomerase activity by HIV Nucleos(t)ide Reverse Transcriptase Inhibitors: a potential factor contributing to HIV-associated accelerated ageing.
  Leeansyah E, Cameron PU, Solomon A, Tennakoon S, Pushparaj Velayudham, Maelenn Gouillou, Tim Spelman, Anna Hearps, Christopher Fairley, De Villiers Smit, Anna B Pierce, Jude Armishaw, Suzanne M Crowe, David A Cooper, Kersten K Koelsch, Jun-Ping Liu, John Chuah, Lewin SR
  J Infect Dis. 2013 Jan; 207(7):1157-65

2012 (3)

• Virologically Suppressed HIV Patients Show Activation of NK Cells and Persistent Innate Immune Activation.
  Lichtfuss GF, Cheng WJ, Farsakoglu Y, Paukovics G, Rajasuriar R, Velayudham P, Kramski M, Hearps AC, Cameron PU, Lewin SR, Crowe SM, Jaworowski A
  J Immunol. 2012 Jun; 189(3):1491-1499
• Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function.
  Hearps AC, Martin GE, Angelovich TA, Cheng WJ, Maisa A, Landay AL, Jaworowski A, Crowe SM
  Aging Cell. 2012 Jun; 11(5):867-875
• HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy.
  Hearps AC, Maisa A, Cheng WJ, Angelovich TA, Lichtfuss GF, Palmer CS, Landay AL, Jaworowski A, Crowe SM
  AIDS. 2012 Apr; 26(7):843-853

2011 (1)

• HIV infection and aging of the innate immune system.
  Hearps AC, Angelovich TA, Jaworowski A, Mills J, Landay AL, Crowe SM
  Sex Health. 2011 Dec; 8(4):453-464

2010 (1)

• Stability of dried blood spots for HIV-1 drug resistance analysis.
  Hearps AC, Ryan CE, Morris LM, Plate MM, Greengrass V, Crowe SM
  Curr HIV Res. 2010 Mar; 8(2):134-140

2009 (4)

• Effect of reverse transcriptase inhibitors and mutations on the low-cost Cavidi reverse transcriptase viral load assay.
  van Rooijen LB, Greengrass V, Morris LM, Plate MM, Gouillou M, Tachedjian G, Sluis-Cremer N, Hearps AC, Crowe SM
  J Acquir Immune Defic Syndr. 2009 Dec; 52(4):527-529
• An HIV-1 integrase genotype assay for the detection of drug resistance mutations.
  Hearps AC, Greengrass V, Hoy J, Crowe SM
  Sex Health. 2009 Dec; 6(4):305-309
• Evaluation of the blood stabilizers TransFix and Cyto-Chex BCT for low-cost CD4 T-cell methodologies.
  Plate MM, Louzao R, Steele PM, Greengrass V, Morris LM, Lewis J, Barnett D, Warrino D, Hearps AC, Denny T, Crowe SM
  Viral Immunol. 2009 Oct; 22(5):329-332
• Evaluation of the Cavidi ExaVir Load assay (version 3) for plasma human immunodeficiency virus type 1 load monitoring.
  Greengrass VL, Plate MM, Steele PM, Denholm JT, Cherry C, Morris LM, Hearps A, Crowe SM
  J Clin Microbiol. 2009 Sep; 47(9):3011-3013

News Articles (10)

2018 (1)

• Dr Anna Hearps is 2018 Gust-McKenzie Medallist

2017 (4)

• Healthy ageing starts early
• Lactic acid's role in protecting women at risk of HIV
• Protection for women at high risk of HIV
• Addressing HIV drug resistance in Papua New Guinea

2016 (2)

• Travel award winners on the move
• HIV researchers meet the community at mHIVE

2012 (2)

• HIV infected people now facing early ageing diseases
• Microbicides: enabling women to protect themselves against HIV

2011 (1)

• Burnet staff and donors recognised at Excellence Awards