Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells.
Fraser JE, Wang C, Chan KWK, Vasudevan SG, Jans DA
A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.
Fraser JE, Watanabe S, Wang C, Chan WKK, Maher B, Lopez-Denman A, Hick C, Wagstaff KM, Mackenzie JM, Sexton PM, Vasudevan SG, Jans DA
Investigating dengue virus nonstructural protein 5 (NS5) nuclear import.
Fraser JE, Rawlinson SM, Wang C, Jans DA, Wagstaff KM
Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.
Tay MYF, Fraser JE, Chan WKK, Moreland NJ, Rathore AP, Wang C, Vasudevan SG, Jans DA
Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 contain reduced cysteine residues essential for virus entry.
Fraser J, Boo I, Poumbourios P, Drummer HE
Hepatitis C