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Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-<i>N</i>-acetylglucosamine.

Soliman C, Walduck AK, Yuriev E, Richards JS, Cywes-Bentley C, Pier GB, Ramsland PA

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  • Journal The Journal of biological chemistry

  • Published 15 Feb 2018

  • Volume 293

  • ISSUE 14

  • Pagination 5079-5089

  • DOI 10.1074/jbc.RA117.001170

Abstract

Additionally, a model of intact F598 binding to two pentasaccharide epitopes indicates that the Fab arms can span at least 40 GlcNAc residues on an extended PNAG chain. Our findings unravel the structural basis for F598 binding to PNAG on microbial surfaces and biofilms.