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  4. Polymorphisms in CAMKK2 associate with susceptibility to sensory neuropathy in HIV patients treated ...

Polymorphisms in CAMKK2 associate with susceptibility to sensory neuropathy in HIV patients treated without stavudine.

Gaff J, Octaviana F, Ariyanto I, Cherry C, Laws SM, Price P

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  • Journal Journal of neurovirology

  • Published 15 Jul 2019

  • Volume 25

  • ISSUE 6

  • Pagination 814-824

  • DOI 10.1007/s13365-019-00771-w

Abstract

 = 0.11). CAMKK2 haplogroup A (includes 16 haplotypes and all instances of rs7975295*C, rs1560568*A, rs1132780*T) associated with reduced rates of HIV-SN (p = 0.02, OR = 0.43 CI = 0.21-0.88). These findings support a protective role for these three alleles, suggesting a role in the pathogenesis of HIV-SN that is independent of stavudine.