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PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion.

Barnes CBG, Dans MG, Jonsdottir TK, Crabb BS, Gilson PR

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  • Journal Frontiers in cellular and infection microbiology

  • Published 30 Nov 2022

  • Volume 12

  • Pagination 1060202

  • DOI 10.3389/fcimb.2022.1060202

Abstract

efflux is critical to the regulation of parasite egress.