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  4. Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding a...

Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity.

Chenoweth AM, Esparon S, Wines BD, Schuurman J, Labrijn AF, Hogarth PM

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  • Journal Immunology and cell biology

  • Published 28 Apr 2023

  • Volume 101

  • ISSUE 7

  • Pagination 657-662

  • DOI 10.1111/imcb.12646

Abstract

E has utility for mAb-mediated immune agonism therapies that are dependent on FcγRIIb interaction and of anti-inflammatory mAbs in allergy and autoimmunity that harness FcγRIIb inhibitory signaling.