Substance misuse can have a negative impact on parenting. For children, having a parent who misuses substances can lead to physical, mental health and social challenges. Parents who use methamphetamine are less likely to have co-resident children than parents who use other substances so it is important to consider how we support these parents, particularly those with children in their care. The aim of this review was to identify, critique and synthesise interventions that support parents who use methamphetamine and who are caring for children. Three original empirical intervention studies involving parents as primary caregivers of children under 18 years of age were found: two postnatal interventions and one group-training intervention for parents with young children. The findings suggest that interventions may have a positive effect on minimising methamphetamine use and supporting parenting but the small number of studies reviewed suggest the evidence is, at best, emerging. It is not clear whether efforts should be directed to support parents and/or their parenting skills and what effect these might have on children’s outcomes. Further research is needed to identify the most effective approaches to supporting this population.