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Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort.

Ataide R, Ashley EA, Powell R, Chan JA, Malloy MJ, O'Flaherty K, Takashima E, Langer C, Tsuboi T, Dondorp AM, Day NP, Dhorda M, Fairhurst RM, Lim P, Amaratunga C, Pukrittayakamee S, Hien TT, Htut Y, Mayxay M, Faiz MA, Beeson JG, Nosten F, Simpson JA, White NJ, Fowkes FJ

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  • Journal Proceedings of the National Academy of Sciences of the United States of America

  • Published 13 Mar 2017

  • Volume 114

  • ISSUE 13

  • Pagination 3515-3520

  • DOI 10.1073/pnas.1615875114

Abstract

mutants compared with wild-type parasites). Naturally acquired immunity accelerates the clearance of artemisinin-resistant parasites in patients with falciparum malaria and may confound the current working definition of artemisinin resistance. Immunity may also play an important role in the emergence and transmission potential of artemisinin-resistant parasites.