close search

Erythropoietin Protects Against Lipopolysaccharide-Induced Microgliosis and Abnormal Granule Cell Development in the Ovine Fetal Cerebellum.

McDougall ARA, Hale N, Rees S, Harding R, De Matteo R, Hooper SB, Tolcos M

VIEW FULL ARTICLE
  • Journal Frontiers in cellular neuroscience

  • Published 28 Jul 2017

  • Volume 11

  • Pagination 224

  • DOI 10.3389/fncel.2017.00224

Abstract

< 0.01). There was no difference between groups in the areas of the vermis (total cross-section), molecular layer (ML), IGL or WM, the density of NeuN-positive granule cells in the ML, the linear density of Bergmann glial fibers, the areal density or somal area of the Purkinje cells, the areal coverage of GFAP-positive astrocytes in the lobular and deep WM, the density of Iba-1-positive microglia in the deep WM or the density of apopotic cells in the cerebellum. LPS-induced intrauterine inflammation caused microgliosis and abnormal development of granule cells. rhEPO ameliorated these changes, suggesting that it is neuroprotective against LPS-induced inflammatory effects in the cerebellum.