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  4. Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte matu...

Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation.

Heil J, Olsavszky V, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS

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  • Journal Nature communications

  • Published 29 Nov 2021

  • Volume 12

  • ISSUE 1

  • Pagination 6963

  • DOI 10.1038/s41467-021-27161-3

Abstract

BM-SEC reveal aberrant sinusoidal differentiation with altered EC gene expression and perisinusoidal ECM deposition and angiocrine dysregulation with de novo endothelial expression of FGF23 and DKK2, elevated in anemia and involved in vascular stabilization, respectively. Our study demonstrates that BM-SEC play an important role in the bone marrow microenvironment in health and disease.