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Bedaquiline overdose: A case report.

Telnov O, Alvarez V, Graglia E, Molfino L, du Cros P, Rich M

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  • Journal International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

  • Published 02 Apr 2019

  • Volume 84

  • Pagination 138-140

  • DOI 10.1016/j.ijid.2019.03.035

Abstract

We present a case report describing outcomes in a 21 year old HIV-negative man who received treatment with bedaquiline. Due to error, dosage received comprised 4 pills of 100 mg every second day in the 60 days following the first two weeks of 4 pills of 100 mg every day. On detection, treatment was continued as per standard dosing of 200 mg given three times per week, with enhanced monitoring of ECG and liver function. The man was asymptomatic, with no signs of jaundice, abdominal pain, or abnormal heart rhythm. Toxic effects at this dosage were therefore not observed.