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Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human <i>Plasmodium falciparum</i> Infections.

van den Hoogen LL, Walk J, Oulton T, Reuling IJ, Reiling L, Beeson JG, Coppel RL, Singh SK, Draper SJ, Bousema T, Drakeley C, Sauerwein R, Tetteh KKA

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  • Journal Frontiers in microbiology

  • Published 16 Jan 2019

  • Volume 9

  • Pagination 3300

  • DOI 10.3389/fmicb.2018.03300

Abstract

< 0.001). Most volunteers developed antibodies against a potential marker of recent exposure: Etramp 5 (37/45, 82%). Our findings justify validation in endemic populations to define a minimum set of antigens needed to detect exposure to natural low-density infections.