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Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study.

O'Flaherty K, Chan JA, Cutts JC, Zaloumis SG, Ashley EA, Phyo AP, Drew DR, Dondorp AM, Day NP, Dhorda M, Fairhurst RM, Lim P, Amaratunga C, Pukrittayakamee S, Hien TT, Htut Y, Mayxay M, Faiz MA, Mokuolu OA, Onyamboko MA, Fanello C, Takashima E, Tsuboi T, Theisen M, Nosten F, Beeson JG, Simpson JA, White NJ, Fowkes FJI

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  • Journal Frontiers in cellular and infection microbiology

  • Published 07 Apr 2022

  • Volume 12

  • Pagination 804470

  • DOI 10.3389/fcimb.2022.804470

Abstract

gametocytes and its association with gametocytemia is essential for understanding the transmission of malaria as well as progressing transmission blocking vaccine candidates.

s48/45 at enrolment in 1,114 participants with clinical falciparum malaria. Mixed effects linear and logistic regression were used to determine the association between gametocyte measures (gametocytemia and gametocyte density) and antibody outcomes at enrolment.

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