Publications & Reports

NF-kappaB subunit specificity in hemopoiesis.

Gerondakis S, Banerjee A, Grigoriadis G, Vasanthakumar A, Gugasyan R, Sidwell T, Grumont RJ
Burnet Institute, Prahran, Vic., Australia. and


Although the diverse functions served by the nuclear factor-kappaB (NF-kappaB) pathway in virtually all cell types are typically employed to deal with stress responses, NF-kappaB transcription factors also play key roles in the development of hemopoietic cells. This review focuses on how NF-kappaB transcription factors control various aspects of thymic T-cell and myeloid cell differentiation that include its roles in hemopoietic precursors, conventional alphabeta T cells, CD4(+) regulatory T cells, natural killer T cells, gammadelta T cells, macrophages, and dendritic cells.


  • Journal: Immunological Reviews
  • Published: 01/03/2012
  • Volume: 246
  • Issue: 1
  • Pagination: 272-285