Publications & Reports

The NF-kappaB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties.

Gugasyan R, Horat E, Kinkel SA, Ross F, Grigoriadis G, Gray D, O'Keeffe M, Berzins SP, Belz GT, Grumont RJ, Banerjee A, Strasser A, Godfrey DI, Tsichlis PN, Gerondakis S
Burnet Institute, Centre for Immunology, Melbourne, Victoria, Australia. gugasyan@burnet.edu.au

Abstract

The role of specific members of the NF-kappaB family of transcription factors in CD8 T-cell selection and development is largely unknown.

Here, we show that mice lacking NF-kappaB1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs.

Development of this memory-like population is not due to PLZF(+) thymocytes and instead coincides with changes in CD8 T-cell selection.

These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells.

These findings indicate that NF-kappaB1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8(+) thymocytes with memory cell characteristics.

Publication

  • Journal: The EMBO Journal
  • Published: 01/02/2012
  • Volume: 31
  • Issue: 3
  • Pagination: 692-706

Author