Publications & Reports

Methods for Living Guidelines: Early Guidance based on practical experience. Paper 3: Selecting and prioritising questions for living guidelines.

Cheyne S, Fraile Navarro D, Buttery AK, Chakraborty S, Crane O, Hill K, McFarlane E, Morgan RL, Mustafa RA, Poole A, Tunnicliffe D, Vogel JP, White H, Whittle S, Turner T; ALEC Methods and Processes Working Group and Collaborators.
Australian Living Evidence Consortium, Cochrane Australia, School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, Australia.


OBJECTIVE: This article is part of a series on methods for living guidelines, consolidating practical experiences from developing living guidelines. It focuses on methods for identification, selection, and prioritisation of clinical questions for a living approach to guideline development. STUDY DESIGN AND SETTING: Members of the Australian Living Evidence Consortium (ALEC), the National Institute of Health and Care Excellence (NICE) and the US Grading of Recommendations, Assessment, Development and Evaluations (GRADE) Network, convened a working group. All members have expertise and practical experience in the development of living guidelines. We collated methods documents on prioritisation from each organisation’s living guidelines, conducted interviews and held working group discussions. We consolidated these to form best-practice principles, which were then edited and agreed on by the working group members. RESULTS: We developed best-practice principles for 1) identification, 2) selection, and 3) prioritisation, of questions for a living approach to guideline development. Several different strategies for undertaking prioritising questions are explored. CONCLUSION: The paper provides guidance for prioritising questions in living guidelines. Subsequent papers in this series explore consumer involvement, search decisions, and methods decisions, that are appropriate for questions with different priority levels.

Link to publisher’s web site


  • Journal: Journal of Clinical Epidemiology
  • Published: 01/03/2023
  • Volume: 155
  • Pagination: 73-83