Publications & Reports

Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders.

Byrnes SJ, Angelovich TA, Busman-Sahay K, Cochrane CR, Roche M, Estes JD, Churchill MJ
School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.

Abstract

Human Immunodeficiency virus (HIV)-associated neurocognitive disorders are a major burden for people living with HIV whose viremia is stably suppressed with antiretroviral therapy. The pathogenesis of disease is likely multifaceted, with contributions from viral reservoirs including the brain, chronic and systemic inflammation, and traditional risk factors including drug use. Elucidating the effects of each element on disease pathogenesis is near impossible in human clinical or ex vivo studies, facilitating the need for robust and accurate non-human primate models. In this review, we describe the major non-human primate models of neuroHIV infection, their use to study the acute, chronic, and virally suppressed infection of the brain, and novel therapies targeting brain reservoirs and inflammation.

Link to publisher’s web site

Publication

  • Journal: Viruses
  • Published: 09/09/2022
  • Volume: 14
  • Issue: 9
  • Pagination: 1997

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