Abstract

OBJECTIVE: Describe changes in sexual behaviour and determinants of unsafe sex among HIV-infected women in the 24 months after delivery. DESIGN:: Cohort analysis nested within a prevention of mother-to-child transmission trial in Burkina Faso (n = 339) and Kenya (n = 432).

METHODS: Women were followed during pregnancy and until 12-24 months after delivery. At each visit, structured questionnaires were administered about sexual activity and condom use, and risk-reduction counselling and condoms were provided.

RESULTS: At study entry, a median 2 months after HIV testing (IQR = 1-4), 411/770 (53.4%) of women reported partner disclosure, increasing to 284/392 (71.9%) at the final visit. Although most partners were supportive following disclosure, between 5%-10% of disclosed women experienced hostile or unsupportive partner responses during follow-up visits. At each visit, about a third of sexually-active women reported unsafe sex (unprotected sex with HIV-uninfected or unknown status partner). In multivariable logistic regression, unsafe sex was 1.70-fold more likely in Kenyan than Burkinabe women (95%CI = 1.14-2.54), and in those with less advanced HIV disease or aged 16-24. Compared to women who disclosed their status to partners and others, unsafe sex was over 6-fold higher in non-disclosers (95%CI = 3.31-12.11), the effect size reducing with increasing disclosure.

CONCLUSIONS: HIV-infected women who recently delivered have a high potential for further HIV transmission, especially as HIV-discordance is common in Africa. Longitudinal care for women, including positive-prevention interventions, is needed within new services providing antiretroviral prophylaxis during breastfeeding - this repeated interface with services could focus on reducing unsafe sex. Much remains unknown about how to facilitate beneficial disclosure.