Publications & Reports

Female genital tract inflammation, HIV co-infection and persistent mucosal Human Papillomavirus (HPV) infections.

Jean-Mari Kriek, Shameem Z Jaumdally, Lindi Masson, Francesca Little, Zizipho Mbulawa, Pamela P Gumbi, Shaun L Barnabas, Jennifer Moodley, Lynette Denny, David Coetzee, Anna-Lise Williamson, Jo-Ann S Passmore
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Abstract

BACKGROUND: Persistent genital infections with high-risk HPV types increase risk of cervical disease and cancer. Since genital inflammation increases HIV acquisition risk and cancer progression, we evaluated whether HPV infection induces cytokine expression in the reproductive tract. METHODS: Genital cytokines concentrations were measured in 93 HIV-infected and 72 uninfected women. HPV typing was done by Roche Linear array. Persistence and clearance of HPV were evaluated using longitudinal data. RESULTS: Infection with HPV did not influence genital cytokine concentrations. In contrast, HIV-infected women had higher IL-1alpha, IL-6, IL-8, IP-10, MCP-1 and G-CSF concentrations compared to HIV-uninfected women, and HPV-infections that were more prevalent, persistent and multi-type. CONCLUSION: HPV did not influence inflammatory cytokine levels in the genital tract, although immune suppression may favor persistence.

Publication

  • Journal: Virology
  • Published: 01/06/2016
  • Volume: 493
  • Pagination: 247-254

Author