Publications & Reports

Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.

Philippe Selhorst, Lindi Masson, Sherazaan D Ismail, Natasha Samsunder, Nigel Garrett, Leila E Mansoor, Quarraisha Abdool Karim, Salim S Abdool Karim, Jo-Ann S Passmore, Carolyn Williamson
Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.

Abstract

We evaluated whether genital inflammation affects the selection of the transmitted virus. Among South African women, we found that preinfection genital inflammation facilitates transmission of less infectious human immunodeficiency virus, but highly infectious viruses are able to establish infection regardless of inflammation status. This suggests that viral phenotype can influence transmission risk.

Publication

  • Journal: Clinical Infectious Diseases
  • Published: 01/01/2017
  • Volume: 64
  • Issue: 1
  • Pagination: 79-82

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Program

Health Issue