Publications & Reports

Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression.

Lindi Roberts, Jo-Ann S Passmore, Carolyn Williamson, Francesca Little, Lisa M Bebell, Koleka Mlisana, Wendy A Burgers, Francois van Loggerenberg, Gerhard Walzl, Joel F Djoba Siawaya, Quarraisha Abdool Karim, Salim S Abdool Karim
Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.

Abstract

BACKGROUND: Both T-cell activation during early HIV-1 infection and soluble markers of immune activation during chronic infection are predictive of HIV disease progression. Although the acute phase of HIV infection is associated with increased pro-inflammatory cytokine production, the relationship between cytokine concentrations and HIV pathogenesis is unknown. OBJECTIVES: To identify cytokine biomarkers measurable in plasma during acute HIV-1 infection that predict HIV disease progression. DESIGN: Study including 40 South African women who became infected with HIV-1 and were followed longitudinally from the time of infection. METHODS: The concentrations of 30 cytokines in plasma from women with acute HIV-1 infection were measured and associations between cytokine levels and both viral load set point 12 months postinfection and time taken for CD4 cell counts to fall below 350 cells/microl were determined using multivariate and Cox proportional hazards regression. RESULTS: We found that the concentrations of five plasma cytokines, IL-12p40, IL-12p70, IFN-gamma, IL-7 and IL-15 in women with acute infection predicted 66% of the variation in viral load set point 12 months postinfection. IL-12p40, IL-12p70 and IFN-gamma were significantly associated with lower viral load, whereas IL-7 and IL-15 were associated with higher viral load. Plasma concentrations of IL-12p40 and granulocyte-macrophage colony-stimulating factor during acute infection were associated with maintenance of CD4 cell counts above 350 cells/microl, whereas IL-1alpha, eotaxin and IL-7 were associated with more rapid CD4 loss. CONCLUSION: A small panel of plasma cytokines during acute HIV-1 infection was predictive of long-term HIV disease prognosis in this group of South African women.

Publication

  • Journal: AIDS
  • Published: 27/03/2010
  • Volume: 24
  • Issue: 6
  • Pagination: 819-831

Author

Program

Health Issue