Publications & Reports

Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum.

Lindi Roberts, Timothy J Egan, Keith A Joiner, Heinrich C Hoppe
Division of Pharmacology, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa.

Abstract

The effects of quinoline antimalarials on endocytosis by Plasmodium falciparum was investigated by measuring parasite hemoglobin levels, peroxidase uptake, and transport vesicle content. Mefloquine, quinine, and halofantrine inhibited endocytosis, and chloroquine inhibited vesicle trafficking, while amodiaquine shared both effects. Protease inhibitors moderated hemoglobin perturbations, suggesting a common role for heme binding.

Publication

  • Journal: Antimicrobial Agents and Chemotherapy
  • Published: 01/05/2008
  • Volume: 52
  • Issue: 5
  • Pagination: 1840-1842

Author

Program

Health Issue