Publications & Reports

CD4 T cell metabolism is a major contributor of HIV infectivity and reservoir persistence.

Taylor HE, Palmer CS


HIV infection is characterized by elevated glycolytic metabolism in CD4 T cells. In their recent study, Valle-Casuso et al. demonstrated that both increased glucose utilization and glutamine metabolism are essential for HIV infectivity and replication in CD4 T cells. Here, we discuss the broader implications of immunometabolism in studies of HIV persistence and their potential to inform new treatment and curative strategies.

Link to publisher’s web site


  • Journal: Immunometabolism
  • Published: 01/01/2020
  • Volume: 2
  • Issue: 1
  • Pagination: :e200005