Publications & Reports

Tuberculosis treatment unmasking leprosy: management of drug-resistant tuberculosis and leprosy co-infection.

Kama K, Huang GKL, M. Taune M, Arura R, Morris L, Kombuk B, Marome A, O’Brien DP


Co-infection with tuberculosis (TB) and leprosy is thought to occur infrequently, but has been reported in settings highly endemic for both infectious diseases. We report for the first time a case where treatment for multidrug-resistant TB (MDR-TB) led to the ‘unmasking’ of clinically silent leprosy through the precipitation of a type-1 immunological reaction. Current treatment regimens for MDR-TB may contain a number of drugs, such as levofloxacin and clofazimine, which also have activity against M. leprae. A treatment regimen containing drugs active against both mycobacterial species may be used to achieve cure. Individual considerations on drug-drug interactions, potential additive toxicities and other comorbidities should be taken into account.

Link to publisher’s web site


  • Journal: Public Health Action
  • Published: 21/09/2019
  • Volume: 9
  • Issue: Supplement 1
  • Pagination: S83-S85