Effect of seminal plasma on functions of monocytes and granulocytes.
Selva KJ, Juno JA, Worley MJ, Chung AW, Tachedjian G, Kent SJ, Parsons MS University of Melbourne, Microbiology and Immunology, Melbourne, Victoria, Australia ; [email protected]
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Abstract
Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 NK cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functions of both neutrophils and monocytes. Additionally, slightly lower SP concentrations (1:2-1:10 dilutions) inhibit granulocyte phagocytosis and oxidative burst of both monocytes and granulocytes. These observations may have implications for HIV-1 infectivity following mucosal exposure.
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