Publications & Reports

Bedaquiline overdose: A case report.

Telnov O, Alvarez V, Gragila E, Molfino L, du Cros P, Rich M
Medecins Sans Frontieres Switzerland, Geneva Switzerland. Electronic address: alex.telnov@geneva.msf.org.

Abstract

We present a case report describing outcomes in a 21 year old HIV-negative man who received treatment with bedaquiline. Due to error, dosage received comprised 4 pills of 100 mg every second day in the 60 days following the first two weeks of 4 pills of 100 mg every day. On detection, treatment was continued as per standard dosing of 200 mg given three times per week, with enhanced monitoring of ECG and liver function. The man was asymptomatic, with no signs of jaundice, abdominal pain, or abnormal heart rhythm. Toxic effects at this dosage were therefore not observed.

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Publication

  • Journal: International Journal of Infectious Diseases
  • Published: 02/04/2019
  • Volume: Epub ahead of print

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