Publications & Reports

The evolving facets of bacterial vaginosis: implications for HIV transmission.

McKinnon LR, Achilles S, Bradshaw CS, Burgener A, Crucitti T, Fredricks DN, Jaspan HB, Kaul R, Kaushic C, Klatt N, Kwon DS, Marrazzo JM, Masson L, McClelland S, Ravel J, van de Wijgert JHHM, Vodstrcil LA, Tachedjian G
University of Manitoba, 8664, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Canada.

Abstract

Bacterial vaginosis (BV) is a common yet poorly understood vaginal condition that has become a major focus of HIV transmission and immunology research. Varied terminologies are used by clinicians and researchers to describe microbial communities that reside in the female reproductive tract, which is driven in part by microbial genetic and metabolic complexity, evolving diagnostic and molecular techniques, and multidisciplinary perspectives of clinicians, epidemiologists, microbiologists, and immunologists who all appreciate the scientific importance of understanding mechanisms that underlie “BV”. This Perspectives article aims to clarify the varied terms used to describe the cervicovaginal microbiota and its “non-optimal” state, under the overarching term of BV. The ultimate goal is to move toward language standardization in future literature that facilitates a better understanding of the impact of BV on female reproductive tract immunology and risk of sexually transmitted infections including HIV.

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Publication

  • Journal: AIDS Research and Human Retroviruses
  • Published: 14/01/2019
  • Volume: 35
  • Issue: 3
  • Pagination: 219-228

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