Publications & Reports

Y-chromosome lineage determines cardiovascular organ T-cell infiltration in the stroke-prone spontaneously hypertensive rat.

Shanzana I Khan, Karen L Andrews, Kristy L Jackson, Basimah Memon, Ann-Maree Jefferis, Man K S Lee, Henry Diep, Zihui Wei, Grant R Drummond, Geoffrey A Head, Garry L Jennings, Andrew J Murphy, Antony Vinh, Amanda K Sampson, Jaye P F Chin-Dusting
Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

Abstract

The essential role of the Y chromosome in male sex determination has largely overshadowed the possibility that it may exert other biologic roles. Here, we show that Y-chromosome lineage is a strong determinant of perivascular and renal T-cell infiltration in the stroke-prone spontaneously hypertensive rat, which, in turn, may influence vascular function and blood pressure (BP). We also show, for the first time to our knowledge, that augmented perivascular T-cell levels can directly instigate vascular dysfunction, and that the production of reactive oxygen species that stimulate cyclo-oxygenase underlies this. We thus provide strong evidence for the consideration of Y-chromosome lineage in the diagnosis and treatment of male hypertension, and point to the modulation of cardiovascular organ T-cell infiltration as a possible mechanism that underpins Y- chromosome regulation of BP.-Khan, S. I., Andrews, K. L., Jackson, K. L., Memon, B., Jefferis, A.-M., Lee, M. K. S., Diep, H., Wei, Z., Drummond, G. R., Head, G. A., Jennings, G. L., Murphy, A. J., Vinh, A., Sampson, A. K., Chin-Dusting, J. P. F. Y-chromosome lineage determines cardiovascular organ T-cell infiltration in the stroke-prone spontaneously hypertensive rat.

Publication

  • Journal: FASEB Journal
  • Published: 01/05/2018
  • Volume: 32
  • Issue: 5
  • Pagination: 2747-2756

Author