Adolescent Health in Myanmar
Support Burnet’s Adolescent Health Programs in Myanmar today.
Support Burnet’s Adolescent Health Programs in Myanmar today.
Support Burnet’s Adolescent Health Programs in Myanmar today.
Support Burnet’s Adolescent Health Programs in Myanmar today.
We analysed GCH1 in symptomatic HIV-associated sensory neuropathy (HIV-SN) in Southern Africans including a ‘pain protective’ 3-SNP haplotype and 6 SNPs, analysed individually and in a 6-SNP haplotype. The ‘pain protective’ 3-SNP haplotype and a 6-SNP haplotype containing these alleles associated with a reduced risk of pain. Another 3-SNP haplotype associated with increased presence of pain. Associations were lost after correction for age, gender and CD4 T-cell count. Linkage disequilibrium differed between our cohort and Caucasians suggesting that these SNPs may not be ideal markers in Africans. Subsequently the role of GCH1 in painful HIV-SN remains possible.