Publications & Reports

Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient.

N Macesic, D Langsford, K Nicholls, P Hughes, D J Gottlieb, L Clancy, E Blyth, K Micklethwaite, B Withers, S Majumdar, S Fleming, J Sasadeusz
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia.

Abstract

Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients.

Publication

  • Journal: American Journal of Transplantation
  • Published: 01/03/2015
  • Volume: 15
  • Issue: 3
  • Pagination: 827-832

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