Publications & Reports

The ins and outs of phosphosignalling in Plasmodium: parasite regulation and host cell manipulation.

Carvalho TG, Morahan B, von Freyend SJ, Boeuf P, Grau G, Bustos JG, Doerig C
Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia.


All eukaryotic cells rely on intracellular signalling to (i) coordinate the hugely complex processes of cellular life, such as cell division and differentiation and, (ii) respond to extracellular signals by mobilizing the appropriate response. Once a signal is sensed by a receptor, it is transmitted to effector machinery through conserved signalling mechanisms, that include (i) production/release of soluble second messengers such as cyclic nucleotide or calcium, (ii) recruitment of downstream pathway elements to specific sites, and (iii) protein modifications. Of the latter, reversible protein phosphorylation by protein kinases and protein phosphatases is undoubtedly the most prominent. Signal transduction pathways whose core components are protein kinase cascades represent a major mechanism of cell signalling in eukaryotes. Research over the last two decades clearly indicates that malaria parasites are no exception.

Link to publisher’s web site


  • Journal: Molecular and Biochemical Parasitology
  • Published: 17/05/2016
  • Volume: 208
  • Issue: 1
  • Pagination: 2-15

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