Publications & Reports

The mouse Fc receptor for IgG (Ly-17): molecular cloning and specificity.

P M Hogarth, M L Hibbs, L Bonadonna, B M Scott, E Witort, G A Pietersz, I F McKenzie


A cDNA clone encoding the mouse Ly-17+ Fc receptor for IgG, isolated from a myelomonocytic cell line, was sequenced and expression of mRNA and the functional Fc gamma R investigated. The receptor is a 301 amino acid transmembrane glycoprotein with two homologous extracellular domains that are also homologous to members of the Ig superfamily. The receptor has four sites of N-linked glycosylation and a long 94 amino acid cytoplasmic tail. Northern analysis, immune complex binding, and serological studies demonstrate that the receptor encoded by the cDNA clone binds mouse IgG gamma 1/2b and rabbit IgG complexes.


  • Journal: Immunogenetics
  • Published: 01/01/1987
  • Volume: 26
  • Issue: 3
  • Pagination: 161-168