Publications & Reports

APTEC: Aptamer-tethered enzyme capture as a novel rapid diagnostic test for malaria.

Dirkzwager R, Kinghorn A, Richards JS, Tanner JA


We report the rapid diagnosis of malaria by aptamer-tethered enzyme capture (APTEC) whereby an aptamer captures biomarker Plasmodium falciparum lactate dehydrogenase (PfLDH) then activity is measured colorimetrically. The robust test was sensitive (limit of detection = 4.9 ngmL-1) and could reliably diagnose malaria in clinical blood samples.


  • Journal: Chemical Communication
  • Published: 11/02/2015
  • Volume: 51
  • Issue: 22
  • Pagination: 4697-4700


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