Publications & Reports

Short communication: antibody responses to human immunodeficiency virus envelope from infections with multiple subtypes utilize the 1F7-idiotypic repertoire.

Matthew S Parsons, Robert J Center, Jean-Pierre Routy, Danielle Rouleau, Roger Leblanc, Mark A Wainberg, Cecile L Tremblay, Marcel D Zannou, Stephen J Kent, Michael D Grant, Nicole F Bernard
Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

Abstract

A common idiotype of anti-HIV antibodies (Abs), designated as 1F7, was recently observed on anti-HIV broadly neutralizing Abs (BnAbs). The presence of the 1F7-idiotype on BnAbs suggests that continuous selection of 1F7-idiotypic Abs may allow these clones to achieve the somatic hypermutation necessary for broad neutralization. As the selection of type-specific BnAbs occurs in the setting of infections with a wide array of HIV subtypes, we investigated Abs from subjects infected with diverse subtypes for the selection of 1F7-idiotypic Abs. We observed the 1F7-idiotype on antiviral Abs in infections with various HIV subtypes. Furthermore, gp140-specific 1F7-idiotypic Abs recognized the gp140 antigens from several HIV subtypes. These results demonstrate that the 1F7-idiotype is a common characteristic of Abs from infections with diverse HIV subtypes, and suggests that early cross-reactivity of 1F7-idiotypic clones may act in conjunction with somatic hypermutation to produce BnAbs.

The link in the lower right of this page downloads a copy of this article published in the journal AIDS Res Hum Retroviruses © [2013] [copyright Mary Ann Liebert, Inc.]; AIDS Res Hum Retroviruses is available online at: http://online.liebertpub.com.

Publication

  • Journal: AIDS Research and Human Retroviruses
  • Published: 01/05/2013
  • Volume: 29
  • Issue: 5
  • Pagination: 778-783

Author

Health Issue

Download