Publications & Reports

HIV and age do not substantially interact in HIV-associated neurocognitive impairment.

Lucette A Cysique, Paul Maruff, Margaret P Bain, Edwina Wright, Bruce J Brew
Neurology Department, Xavier Building, Level 4, St. Vincent's Hospital, Darlinghurst, Sydney 2010, NSW, Australia. [email protected]


The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Forty-two percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status x age, both including dementia cases (p=0.12) and excluding dementia cases (p<0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with long-term infection. Further longitudinal studies are warranted.


  • Journal: The Journal of Neuropsychiatry and Clinical Neurosciences
  • Published: 01/01/2011
  • Volume: 23
  • Issue: 1
  • Pagination: 83-89