Publications & Reports

Ly6d-L, a cell surface ligand for mouse Ly6d.

Apostolopoulos J, McKenzie IF, Sandrin MS
Molecular Immunogenetics and Transplantation Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia.


The mouse Ly6 gene family encodes proteins found in lymphocytes and other cells. Some are involved in cell activation; no ligands have been found. A ligand for Ly6d (ThB) was identified on lymphocytes using microspheres loaded with Ly6d and the cDNA isolated from a spleen/thymus library by panning on Ly6d. The Ly6d ligand (Ly6d-L) is a nonglycosylated protein of 9 kDa of broad distribution, rich in cysteine, with no discernable transmembrane sequence. Its N and C termini are on the cell surface, where it associates with a 30 kDa protein. Ly6d-L is homologous with an EGF repeat of Notch.


  • Journal: Immunity
  • Published: 01/02/2000
  • Volume: 12
  • Issue: 2
  • Pagination: 223-232