Publications & Reports

Hepatitis B virus exposure and vaccination in a cohort of people who inject drugs: What has been the impact of targeted free vaccination?

Winter RJ, Dietze PM, Gouillou M, Hellard ME, Robinson P, Aitken CK
Macfarlane Burnet Institute for Medical Research and Public Health; School of Public Health, La Trobe University; School of Public Health and Preventive Medicine, Monash University.


BACKGROUND AND AIM: Forty per cent of new hepatitis B virus (HBV) infections in Australia occur in people who inject drugs (PWID); long-term infection carries the risk of serious liver disease. HBV incidence among Australian PWID has not been measured since the advent of targeted (2001) and adolescent school-based ‘catch-up’ (1998) vaccination programs. We measured HBV incidence and prevalence in a cohort of PWID in Melbourne, Australia and examined demographic and behavioural correlates of exposure and vaccination. METHODS: Community-recruited PWID were surveyed about blood-borne virus risk behaviours and their sera tested for HBV markers approximately three-monthly over three years. Incidence was assessed using prospectively collected data. A cross-sectional design was used to examine prevalence of HBV exposure and vaccination at baseline. Poisson regression was used to identify correlates of HBV exposure and vaccination. RESULTS: At baseline 33.1% of participants (114/344) had been vaccinated against HBV, 40.4% (139/344) had been exposed (previously or currently infected) and 26.5% (91/344) were susceptible. HBV incidence was 15.7 per 100 person-years. Independent associations with HBV exposure included female gender, South-East Asian ethnicity, drug treatment in the past three months, injecting in prison, and prior exposure to hepatitis C virus. Independent associations with vaccination included being </=25 years old, reporting HBV vaccination and never having been to prison. CONCLUSIONS: HBV infection continues at high incidence among Australian PWID, despite the introduction of free vaccination programs. Innovative methods are needed to encourage PWID to complete HBV vaccination.

Full text of is the peer reviewed unformatted version of this article (at link in lower right corner of this page), which has been published in final form by Wiley (DOI: 10.1111/jgh.12063). This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.


  • Journal: Journal of Gastroenterology and Hepatology
  • Published: 01/01/2013
  • Volume: 28
  • Issue: 2
  • Pagination: 314-322


Health Issue