Publications & Reports

Noncanonical peptides in complex with MHC class I.

Apostolopoulos V, Lazoura E
The Austin Research Institute, Immunology and Vaccine Laboratory, Studley Road, Heidelberg, VIC 3084, Australia. v.apostolopoulos@ari.unimelb.edu.au

Abstract

The major histocompatibility complex (MHC) presents canonical medium-high-affinity peptides on the surface of antigen-presenting cells to T-cells. Recognition of peptide MHC by T-cells initiates a cascade of signals which maintains a T-cell-dependent immune response. In the design of vaccines, there is need for an understanding of how peptides bind to MHC class I molecules. Herein, the presentation of canonical anchor motif peptides to MHC class I, noncanonical anchor motif peptides, low-affinity peptides, peptides making use of new pockets, short peptides, long peptides, glycopeptides, retro-inverso peptides and prediction programs for peptides binding to MHC class I molecules is discussed. All this information will aid in the design of new and improved peptide-based vaccines.

Publication

  • Journal: Expert Review of Vaccines
  • Published: 01/04/2004
  • Volume: 3
  • Issue: 2
  • Pagination: 151-162