Publications & Reports

Interferon-gamma therapy activates human monocytes for enhanced phagocytosis of Mycobacterium avium complex in HIV-infected individuals.

Kedzierska K, Paukovics G, Handley A, Hewish M, Hocking J, Cameron PU, Crowe SM
AIDS Pathogenesis Research Unit, Macfarlane Burnet Institute for Medical Research and Public Health, and Department of Medicine, Monash University, Melbourne, Victoria, Australia.

Abstract

Defective immunological function of cells of the macrophage lineage contributes to the pathogenesis of HIV-1 infection. Because monocyte/macrophage function is enhanced by cytokines such as interferon-gamma (IFN-gamma), the use of this immunomodulator is of potential clinical interest as adjunctive immunotherapy in immunosuppressed individuals. In this study, we show that adjunctive IFN-gamma treatment in an HIV-infected individual with Mycobacterium avium complex (MAC) infection increased phagocytosis of MAC by blood monocytes when compared to cells from an HIV-infected patient who was receiving standard chemotherapy alone. Enhanced phagocytic efficiency resulting from IFN-gamma therapy was associated with increased surface expression of MHC II (HLA-DR), a phagocytic receptor (CD16), and the activation marker (CD69), although the levels of activation markers were dissimilar at baseline in the two participants. These results imply that IFN-gamma may be useful in restoring antimycobacterial function in immunosuppressed patients.

Publication

  • Journal: HIV clinical trials
  • Published: 01/03/2004
  • Volume: 5
  • Issue: 2
  • Pagination: 80-85

Author

Health Issue