Publications & Reports

Antibody persistence six years after two doses of combined hepatitis A and B vaccine.

Burgess MA, McIntyre PB, Hellard M, Ruff TA, Lefevre I, Bock HL
Centre for Immunization Research, The Children's Hospital at Westmead, Cnr Hainsworth Street and Hawkesbury Road, Locked Bag 4001, Westmead, Sydney, NSW 2145, Australia.


Persistent immunity to hepatitis A and hepatitis B antibodies six years after vaccination of adolescents (aged 12-15 years) with a combined hepatitis A and B (HAB) vaccine following a 0, 6 month or a 0, 12 month schedule was assessed. Yearly (Year-2-6) serum samples were tested for anti-HAV and anti-HBs using EIA. Subjects with anti-HBs concentrations or = 10 mIU/mL. All but one of the 14 boosted subjects responded to the additional HBV vaccine dose with anti-HBs concentrations > or = 100 mIU/mL. All seroconverted subjects who returned at Year-6 were seropositive for anti-HAV. Simplification, reduced number of doses and similar long-term persistence of immunity make the 0, 6 month and 0, 12 month schedule preferable for immunization against HAV/HBV in this population.


  • Journal: Vaccine
  • Published: 02/03/2010
  • Volume: 28
  • Issue: 10
  • Pagination: 2222-2226