Publications & Reports

MHC and MHC-like molecules - structural perspectives on the design of molecular vaccines.

Apostolopoulos V, Yuriev E, Lazoura E, Yu MM, Ramsland PA
Burnet Institute at Austin, Heidelberg, VIC 3084, Australia. [email protected]


Major histocompatibility complex (MHC) molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells (APCs) to T cell receptors. Recognition of peptide-MHC complexes by T cells initiates a cascade of signals in T cells and activated cells either destroy or help to destroy the APC. The MHCs are divided into three subgroups: MHC class I, MHC class II and MHC class III. In addition, non-classical MHC molecules and MHC-like molecules play a pivotal role in shaping our understanding of the immune response. In the design of molecular vaccines for the treatment of diseases, an understanding of the three-dimensional structure of MHC, its interaction with peptide ligands, and its interaction with the T cell receptor are important prerequisites, all of which are discussed herein.


  • Journal: Human Vaccines
  • Published: 01/11/2008
  • Volume: 4
  • Issue: 6
  • Pagination: 400-409