Publications & Reports

Impaired HCV-specific IFN-gamma responses in individuals with HIV who acquire HCV infection correlate with levels of CD4 cells.

Flynn JK, Dore GJ, Matthews G, Hellard M, Yeung B, Rawlinson WD, White PA, Kaldor JM, Lloyd AR, Ffrench RA; on behalf of the ATAHC Study Group.
Centre for Immunology, Burnet Institute, Melbourne, Australia.


Studies examining the effect of HIV/HCV co-infection on the HCV-specific immune response in acute HCV infection are limited. This study directly compared acute HCV-specific T cell responses and cytokine profiles between 20 HIV/HCV co-infected and 20 HCV mono-infected subjects, enrolled in the Australian Trial in Acute Hepatitis C (ATAHC), using HCV peptide ELISpot and multiplex in vitro cytokine production assays. HIV/HCV co-infection had a detrimental effect upon the HCV-specific cytokine production in acute HCV infection, particularly on HCV-specific IFN-gammaproduction (magnitude p=0.004, breadth p=0.046), which correlated with peripheral CD4 counts (rho=0.605, p=0.005), but not with detectable HIV viraemia (rho=0.152, p=0.534).


  • Journal: The Journal of Infectious Diseases
  • Published: 04/09/2012
  • Volume: 206
  • Issue: 10
  • Pagination: 1568-1576