Publications & Reports

Normal CD16 expression and phagocytosis of Mycobacterium avium complex by monocytes from a current cohort of HIV-1-infected patients.

Jaworowski A, Ellery P, Maslin CL, Naim E, Heinlein AC, Ryan CE, Paukovics G, Hocking J, Sonza S, Crowe SM
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, and Department of Medicine, Monash University, Clayton, Australia. anthonyj@burnet.edu.au

Abstract

Monocyte phenotype and function were measured in whole blood sampled from a current cohort of human immunodeficiency virus (HIV)-infected individuals attending a large, metropolitan, university-affiliated hospital.

There was no significant difference in the prevalence of CD16+ monocytes or the capacity of monocytes to ingest heat-killed Mycobacterium avium complex between these individuals and HIV-uninfected control subjects, regardless of viral load, current CD4+ T cell count, nadir CD4+ T cell count, or time since diagnosis of HIV infection. CD16+ monocyte prevalence was, however, elevated in patients not currently receiving antiretroviral therapy.

We conclude that HIV type 1 infection in the setting of highly active antiretroviral therapy is associated with normal monocyte function and phenotype.

Publication

  • Journal: The Journal of Infectious Diseases
  • Published: 01/03/2006
  • Volume: 193
  • Issue: 5
  • Pagination: 693-697

Author