A novel gel for targeting vaginal inflammation to prevent HIV transmission
Adolescent girls and young women are disproportionately affected by HIV in sub-Saharan Africa where they are up to 8 times more likely to be infected compared to their male counterparts.
A major biological mechanism driving this increased risk is subclinical genital inflammation due to the presence of “non-optimal” vaginal microbiota depleted of beneficial lactobacillus species.
This study will formulate and perform preclinical safety studies of an anti-inflammatory microbiota metabolite for in-vivo evaluation.
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