Low birth weight in Papua New Guinea is a killer. Help us research what is causing low birth weight in PNG so that we can stop it.
This project focuses on the importance of antibody subclass for immunity malaria.
Previous studies have shown that individuals living in malaria endemic areas develop IgG antibodies to the malaria parasite. There are four subclasses of IgG antibodies (IgG1, IgG2, IgG3 and IgG4) and the different antibody subclasses interact with component of the immune system and lead to different effector functions.
Interestingly, individuals that develop natural immunity to malaria mainly develop IgG1 and IgG3. We aim to understand how these subclasses function and which are the most effective against the malaria parasite.
Towards this, we have expressed antibodies with the same antigen binding sites and different subclass backbone. These antibodies will be used to understand the importance of subclasses in functional assays against the malaria parasite. This work will highlight which subclasses should be induced in new vaccines to ensure the most efficient immune response against the malaria parasite.