Projects

Discovery of intrinsic antiviral factors in a major viral reservoir

Bats are an abundant mammalian species and are a major reservoir of viral zoonosis. Since bats predate humans, we predict that they have developed mechanisms to successfully coexist with viral pathogens in the absence of disease development.

Fundamental studies in this area could reveal novel antiviral strategies used by these species to combat human viral pathogens. This study is focused on elucidating the bat repertoire of intrinsic antiviral factors and their activity and mode of action of novel factors against retroviruses and other viral pathogens.

As a result of funding from Perpetual Trustees we were able to carry out studies to discover and characterise versions of the novel intrinsic defense factor, APOBEC3, found in the Pteropus alecto fruit bat.

This could have benefits to HIV-infected individuals in the long-term providing clues for the development of novel therapies.

Publications

2018

Collaborators

  • Linfa Wang, CSIRO Geelong
  • Mary Tachedjian, CSIRO Geelong
  • Zhengli Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
  • Peng Zhou, CSIRO Geelong
  • Michelle Baker, CSIRO AAHL, Geelong
  • Glenn Marsh, CSIRO AAHL, Geelong

Funding

Contact Details

For any general enquiries relating to this project, please contact:

Professor Gilda Tachedjian

Head of Life Sciences; Head of Tachedjian Laboratory (Retroviral Biology and Antivirals)

Telephone

+61392822256

Email

gilda.tachedjian@burnet.edu.au