Impact of declining transmission on immunity and risk of malaria rebound
One potential impact of the roll-out of malaria interventions, including mass drug administration (MDA), is malaria rebound after elimination which is thought to be due to the loss of naturally acquired malaria immunity. However, the timelines for this is unknown and is required in order to inform appropriate malaria interventions and surveillance strategies.
Utilising data from malaria intervention trials in the Greater Mekong region, we seek to quantify the impact of malaria control measures including MDA (and therefore potential elimination) on malaria immunity within communities and how this predicts epidemiological patterns of disease over time.
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